Mitochondrial dynamics in Parkinson's disease
نویسندگان
چکیده
منابع مشابه
Mitochondrial dynamics in disease.
1707 M are subcellular organelles that coordinate numerous metabolic reactions, including those of the respiratory complexes that produce the ATP that powers cellular reactions. They have often been depicted as static, with a kidneybean shape, but there is a growing appreciation of their dynamic nature.1,2 Moreover, they are strikingly varied in structure, ranging from small, spherical particle...
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The meaning of the word mitochondrion (from the Greek mitos, meaning thread, and chondros, grain) illustrates that the heterogeneity of mitochondrial morphology has been known since the first descriptions of this organelle. Such a heterogeneous morphology is explained by the dynamic nature of mitochondria. Mitochondrial dynamics is a concept that includes the movement of mitochondria along the ...
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One of the characteristic symptoms of patients with Parkinson Disease (PD) is a rigidity of movement. These symptoms disappear after administration of Levodopa. However, the long-term use of levodopa causes involuntary movements (dyskinesia). A proper diagnosis requires an automatic, unsupervised method for the detection and classification of levodopa induced dyskinesia. The main problem, howev...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2009
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2009.03.019